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对人体钩虫的动物模型研究,很久以来就受到国内外研究者的重视,但至今未找到一种理想的动物。四川省寄生虫研究所应用免疫抑制剂,以长爪沙鼠、幼犬为实验动物,证实人体钩虫可在该种动物体内发育成成虫,且可交配产卵;印度Bho-pal,M.K等人于1978年报告,以幼兔作动物模型,不用免疫抑制剂,证实出生2天的幼免对美洲钩蚴有高度易感性,钩虫在幼兔体内可完全发育,感染后60～150天每克兔粪含卵量高达10,000个以上,且幼兔感染后的病理变化与人相似,认为
Animal models of human hookworm have long been valued by researchers at home and abroad, but so far no ideal animal has been found. Sichuan Institute of Parasitology application of immunosuppressive agents to gerbils, puppies as experimental animals, confirmed that human hookworm can develop into adults in the animal body, and can be mating spawning; India Bho-pal, MK et al In 1978, the report of young rabbits as an animal model, without immunosuppressive agents, confirmed that two days of birth-free hypersensitization of the United States Echinococcus has a high susceptibility to hookworm in rabbits can be fully developed in vivo 60 to 150 days after infection per gram Rabbit fecal egg as high as 10,000 or more, and pathological changes after infection in rabbits and people similar to that