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早在2001年由MoGarry~([1])首先提出游离脂肪酸(FFA)和甘油三酯(TG)升高超过脂肪组织的储存能力和各组织对FFA的氧化能力时,就会以TG形式在非脂肪组织沉积,而损伤各组织,沉积在β细胞造成胰岛功能损伤,沉积在心形成肥胖性心肌病,沉积在肌肉导致周围胰岛素抵抗,沉积在肝就形成脂肪性肝病而导致肝性抵抗,沉积在脂肪组织,超越脂肪组织的储存能力,导致脂肪细胞数目增
As early as 2001 by MoGarry ~ ([1]) first proposed free fatty acids (FFA) and triglycerides (TG) rose more than the storage capacity of adipose tissue and the organization’s ability to FFA oxidation, it will be in the form of TG Non-adipose tissue deposition, which damages tissues, deposits in the beta cell, causes islet dysfunction, deposits in the heart to form obese cardiomyopathy, deposition in the muscle leads to peripheral insulin resistance, deposition in the liver leads to fatty liver disease leading to hepatic resistance, deposition In adipose tissue, the ability to accumulate beyond adipose tissue results in an increase in the number of adipocytes