论文部分内容阅读
应用双抗体夹心法检测了５４例慢性乙型肝炎、肝硬化患者血清可溶性白介素２受体（ｓＩＬ－２Ｒ），以及应用单克隆抗体和ＡＰＡＡＰ法对Ｔ淋巴细胞亚群进行了检测，结果显示慢性乙型肝炎病人血清ｓＩＬ－２Ｒ明显高于对照组，并且其升高与血清胆红素水平相关；而病人ＯＫＴ３细胞与正常对照无显著差异，ＯＫＴ４阳性细胞比例下降，ＯＫＴ８阳性细胞比例增加，ＯＫＴ４／ＯＫＴ８比值下降，各临床类型中以重症肝炎ＯＫＴ４／ＯＫＴ８比值下降显著，其次为慢活肝，说明随着肝细胞损伤程度加重，免疫紊乱状态更加严重。
Serum soluble interleukin 2 receptor (sIL-2R) was detected in 54 patients with chronic hepatitis B and cirrhosis by double antibody sandwich method. T lymphocyte subsets were detected by monoclonal antibody and APAAP assay. The serum sIL-2R of patients with hepatitis B was significantly higher than that of the control group, and the level of serum sIL-2R was correlated with the level of serum bilirubin. However, there was no significant difference between the OKT3 cells and the normal controls, the percentage of OKT4 positive cells decreased and the percentage of OKT8 positive cells increased. / OKT8 ratio decreased in all clinical types of severe hepatitis OKT4 / OKT8 ratio decreased significantly, followed by a slow living liver, indicating that as the degree of hepatocellular injury, immune disorders even worse.