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本文报告123例年龄已过青春期的重症慢性活动性肝病(简称CALD)患者,按作者等所采用的方案(见Gut 16:876,1975)使用皮质类固醇治疗,有69例(占56％)取得缓解。缓解标准:症状消失;SGOT活性降至正常值的两倍以下,其他常规肝功能试验(血清γ球蛋白和胆红素)在正常范围内;肝活检显示病理变化完全消退或仅示非特异性肝炎病变,即汇管区遗有慢性炎症细胞浸润(伴/无极轻微碎片样坏死)或虽有肝硬化表现(即指肝纤维化并至少有一个完整的再生结节),但并无(或仅伴有轻度)炎症变化。
This article reports 123 patients with severe chronic active liver disease (PADD) who have passed their adolescence and was treated with corticosteroids according to the protocol used by the authors (see Gut 16: 876, 1975), of which 69 (56%) were obtained ease. Mitigating criteria: symptoms disappeared; SGOT activity dropped to less than twice normal; other routine liver function tests (serum gamma globulin and bilirubin) were within normal limits; liver biopsy showed complete regression of pathological changes or nonspecific hepatitis Lesions, which are left in the portal area with chronic inflammatory cell infiltration (with / without minor debris-like necrosis) or despite cirrhosis (ie, fibrosis and at least one complete regenerative nodule), but not (or only Mild) inflammation changes.