肿瘤转移相关基因 1(MTA1)是NuRD的亚单位之一,它通过促进组蛋白脱乙酰基,影响基因的转录和复制。研究发现,它与乳腺癌、食道癌、胃肠癌、胰腺癌等多种人类上皮源性肿瘤侵袭转移的能力紧密相关,它的高表达与肿瘤的侵袭深度与病理分级呈正相关,可作为评价预后的一个指标。 Tumor metastasis-associated gene 1 (MTA1), one of NuRD’s subunits, affects the transcription and replication of genes by promoting histone deacetylation. The study found that breast cancer, esophageal cancer, gastrointestinal cancer, pancreatic cancer and other human epithelial tumor invasion and metastasis is closely related to its high expression and tumor invasion depth and pathological grade was positively correlated, can be used as an evaluation An indicator of prognosis.