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终末期肾病患者普遍存在高磷血症,而高磷血症是终末期肾病患者死亡率和心血管疾病发生率增高的重要因素。另外高磷血症还可引起甲状旁腺功能亢进、骨营养不良、转移性钙化等,因此有效控制血清磷水平是终末期肾病一体化治疗的重要措施。目前高磷血症的治疗主要包括饮食限磷、透析治疗、磷结合剂的应用及必要时甲状旁腺的切除。本文将具体介绍各种磷结合剂用于治疗高磷血症的研究进展。
Hyperphosphatemia is common in patients with end-stage renal disease, and hyperphosphatemia is an important factor in the mortality and cardiovascular disease in patients with end-stage renal disease. In addition, hyperphosphatemia can cause hyperparathyroidism, osteodystrophy, metastatic calcification, and so effective control of serum phosphorus level is an important measure for the treatment of end-stage renal disease. The current treatment of hyperphosphatemia include diet phosphorus, dialysis treatment, the application of phosphate binding agent and if necessary parathyroid gland resection. This article will detail the various phosphorus binding agent for the treatment of hyperphosphatemia research progress.