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氨甲环己烷羧酸(Tranexamie acid,TA)是一种抗纤溶药,其作用与6-氨基己酸相似。本文报告用TA治疗上消化道出血的双盲法研究结果。200例住院患者随机分组:TA组103例,安慰剂组97例。TA组给予TA1克静滴及1克口服,每8小时1次共48小时,嗣后每8小时继给1克口服,共72小时;对照组则用安慰剂。两组的基础资料是可对比的。年龄均多在50岁以上,男性居多;入院就诊时均以中量失血(200～1,000毫升)为主;可询及的诱因以阿司匹林和酒精为多。全部患者的出血病因也相似,计有十二指肠和幽门溃疡、胃溃疡、急性胃糜烂、食管静脉曲张、食管炎、食管-贲门连接处撕裂等,经钡餐、内窥镜、手术和尸检所证实。
Tranexamie acid (TA) is a anti-fibrinolytic drug that acts like 6-aminocaproic acid. This article reports the results of a double-blind study using TA in the treatment of upper gastrointestinal bleeding. 200 inpatients were randomized to receive TA in 103 patients and placebo in 97 patients. TA group received intravenous infusion of TA1 g and 1 g orally, once every 8 hours for a total of 48 hours, followed by every 8 hours for 1 g orally for a total of 72 hours. The control group received a placebo. The two sets of basic data is comparable. Both were over 50 years of age, mostly men; admission were moderate blood loss (200 ~ 1,000 ml) based; available incentives to aspirin and alcohol as much. All patients with similar causes of bleeding, including duodenal and pyloric ulcer, gastric ulcer, acute gastric erosion, esophageal varices, esophagitis, esophageal - cardia junction tear, barium meal, endoscopy, surgery and Autopsy confirmed.