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目的研究活动期RA患者血清中细胞因子IL-18的表达,并探讨它们与疾病活动程度的关系。方法 2008年12月-2010年1月将63例RA患者,根据DAS28将患者分为高度活动组和低度活动组,应用酶联免疫吸附法(ELISA)法检测63例RA患者和27例对照组的白细胞介素-18(IL-18)表达水平。分析IL-18的水平与临床指标的相关性。结果 IL-18在活动期RA中表达水平高于低度活动组、对照组,分别为(238.88±41.75)、(189.11±40.62)、(185.42±44.93)pg/mL,有统计学意义(P<0.01)。RA活动组患者IL-18与外周血白细胞计数呈负相关(r=-0.628,P<0.05)。结论 IL-18水平在RA活动期患者高表达,在RA发病和发展中起重要作用。
Objective To study the expression of cytokines IL-18 in serum of patients with active RA and to explore their relationship with the degree of disease activity. Methods From December 2008 to January 2010, 63 RA patients were divided into high activity group and low activity group according to DAS28. 63 RA patients and 27 control patients were detected by enzyme-linked immunosorbent assay (ELISA) Group of interleukin-18 (IL-18) expression levels. Analysis of IL-18 levels and clinical indicators of relevance. Results The expression level of IL-18 in active RA was higher than that in low activity group (238.88 ± 41.75), (189.11 ± 40.62) and (185.42 ± 44.93) pg / mL, respectively <0.01). There was a negative correlation between IL-18 and peripheral blood leukocyte count in patients with RA activity (r = -0.628, P <0.05). Conclusion IL-18 is highly expressed in RA patients and plays an important role in the pathogenesis and progression of RA.