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患者男,35岁,因胸、背部大疱、糜烂3个月,结合组织病理及直接、间接免疫荧光检查诊断为寻常型天疱疮。给予硫唑嘌呤100mg/d和丙酸氯倍他索外擦治疗,7天后出现发热(最高39.5℃)并伴广泛性关节痛、肌痛和头痛。停用硫唑嘌呤后48小时内症状完全消失。10天后再给予25mg硫唑嘌呤,24小时后又出现上述症状。硫唑嘌呤的上述副作用是十分罕见的。这种过敏类型似与原发病无关。虽然在治疗节段性回肠炎,肾小球肾炎,溃疡性结肠炎,类风湿性关节炎,多发性硬化症及1例大疱性类天疱疮中有过报道,但尚未见于寻常型天疱疮中。这种超敏反应可见于两性中,多发生在60岁年龄组,与药
The patient, male, 35 years old, was diagnosed as pemphigus vulgaris by chest and back bullae and erosions for 3 months in combination with histopathology and direct and indirect immunofluorescence. Administration of azathioprine 100 mg / day and clobetasol propionate outside the rub resulted in fever (max. 39.5 ° C) 7 days later with extensive joint pain, myalgia and headache. Symptoms disappeared completely within 48 hours after the withdrawal of azathioprine. After 10 days and then given 25mg azathioprine, 24 hours after the above symptoms. The above mentioned side effects of azathioprine are very rare. This type of allergy does not seem to be related to the primary disease. Although reported in the treatment of Crohn’s disease, glomerulonephritis, ulcerative colitis, rheumatoid arthritis, multiple sclerosis and one case of bullous pemphigoid, it has not yet been found in the common type Pemphigus. This hypersensitivity can be seen in both sexes, mostly in the 60-year-old age group, with the drug