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An efficient synthesis of Biginelli-type compounds using potassium phthalimide as a green,mild,and commercially available organocatalyst in a one-pot,multi-component cyclocondensation reaction of cyclopentanone,aldehydes,and urea/thiourea is reported.The present methodology is a green approach to access 4-aryl-7-(aryImethylene)-3,4,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-2(5H)-ones/thiones.It offers several merits such as simple operational procedures,no use of hazardous organic solvents,and cheap and environmentally friendly solid basic catalyst.
An efficient synthesis of Biginelli-type compounds using potassium phthalimide as a green, mild, and commercially available organocatalyst in a one-pot, multi-component cyclocondensation reaction of cyclopentanone, aldehydes, and urea / thiourea is reported. route to access 4-aryl-7- (aryImethylene) -3,4,6,7- tetrahydro-1H-cyclopenta [d] pyrimidin- 2 (5H) -ones / thiones.It offers several merits such as simple operational procedures, no use of hazardous organic solvents, and cheap and environmentally friendly solid basic catalyst.