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我们从1982年9月1日至83月元月30日,对临床可疑卵巢恶性肿瘸患者均于术前取外周血作细胞培养,并进行染色体G分带检查。经术后病理证实为卵巢恶性肿瘸者共5例,将此5例之G-带型染色体与5例经病理检查诊断为良性卵巢肿瘤患者经同法制备之外周血G-带型染色体进行比较。恶性组每例数50～60个细胞,良性组每例各数50个细胞。检查结果发现恶性组亚二倍体细胞非常显著高于良性组(P<0.001),超二倍细胞亦非常显著增高(P<0.001)。 另有一例卵巢乳头状癌仅作患侧卵巢切除术后6个月,检查100个细胞,其亚二倍体细胞与超二倍体细胞均非常显著高于良性组(P<0.001),且有结构异常。 本文认为这些具有异常染色体的细胞为淋巴细胞,外周血淋巴细胞染色体的变化有可能做为预测卵巢恶性肿瘤的诊断、并作为术后随访及指导治疗之手段。外周血标本来源较易、培养方法简单、成功率亦高,所以是一种可取的检查方法。
We from September 1, 1982 to August 30 January 30, clinical suspicion of ovarian cancer patients with malignant lavage were preoperative peripheral blood cells for cell culture, and chromosome G banding. The postoperative pathology confirmed as ovarian malignant lame in a total of 5 cases, the 5 cases of G-banding chromosomes and 5 cases of pathologically diagnosed as benign ovarian tumor patients by the same method of preparation of peripheral G-banding chromosomes Compare Each malignant group of 50 to 60 cells, benign group of 50 cases of each cell number. The results showed that the subdiploid cells in malignant group were significantly higher than those in benign group (P <0.001) and in super diploid cells (P <0.001). Another case of papillary carcinoma of the ovary only for ipsilateral ovariectomy 6 months after the examination of 100 cells, the sub-diploid cells and diploid cells were significantly higher than the benign group (P <0.001), and A structural abnormalities. In this paper, we think that these abnormal chromosomes are lymphocytes. The changes of peripheral blood lymphocyte chromosomes may be used as a prediction for the diagnosis of ovarian malignant tumors and as a means of follow-up and guiding treatment. Peripheral blood samples easier source, culture method is simple, the success rate is also high, so it is a desirable method of inspection.