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目的探讨奥扎格雷钠及还原型谷胱甘肽治疗老年急性一氧化碳中毒的疗效。方法老年既往无严重慢性病的中、重度急性一氧化碳中毒患者,分为治疗组及对照组各17人。治疗组加用奥扎格雷钠80mg,1～2次/d;加用还原型谷胱甘肽1.2～1.8分,1次/d。10～15d为1个疗程。结果所有患者均存活,选取入院第5天时的GCS评分,治疗组(12.35±2,61)d,对照组(11.00±2.94)d,P>0.05;两周时GCS大于12的例数,治疗组12例,对照组9例,其中治疗组达GSC达12需要的天数(2.18±1.09)d,治疗组为(3.00±1.34)d,P<0.05;第20～30天时治疗组Barthel指数(70.89±28.58)d,对照组(62.65±26.29)d,P 0.05. Group (n = 12) and control group (n = 9). The number of days required for GSC up to 12 in treatment group was (2.18 ± 1.09) d, and the treatment group was (3.00 ± 1.34) 70.89 ± 28.58) d, the control group (62.65 ± 26.29) d, P <0.05; the MMSE treatment group (25.06 ± 3.86) d on the 20th to 30th day and the control group (22.94 ± 4.80) days, P <0.05. There were significant differences in Barthel and MMSE between the treatment group and Glasgow at two weeks when GCS was greater than 12. Conclusion The experimental group in daily living ability and intelligence recovered better.