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目的:研究胃疡宁丸对胃肠运动的影响。方法:将实验动物随机分为对照组、胃疡宁低、中、高剂量(0.395,0.79,1.58 g.kg-1)组、胃康宁组(0.4 g.kg-1)、吗丁啉组(0.05 g.kg-1),进行硫酸酮致家鸽呕吐实验,测定呕吐潜伏期和呕吐频率;进行大鼠在体肠运动实验、正常离体兔肠运动实验、乙酰胆碱所致痉挛离体兔肠运动实验,测定给药前后张力,并计算抑制率。结果:胃疡宁丸能够减少家鸽呕吐频率(P<0.05或P<0.01),抑制大鼠在体肠的收缩(P<0.01),并且对正常离体兔肠收缩与乙酰胆碱所致离体兔肠痉挛有明显抑制作用。结论:胃疡宁丸有胃肠解痉、止呕的作用与其抑制胃肠运动有关。
Objective: To study the effect of Weiyangning Pills on gastrointestinal motility. Methods: The experimental animals were randomly divided into control group, gastric ulcer low, medium and high doses (0.395,0.79,1.58 g.kg-1), stomach Corning group (0.4 g.kg-1), domperidone group (0.05 g.kg-1), ketogenic Ketogenic pigeon pigeon experiments were conducted to determine the vomiting latency and vomiting frequency; rats in the intestine movement test, normal rabbit intestine movement test, induced acetylcholine spasm isolated rabbit intestine Exercise test, measured before and after administration of tension, and calculate the inhibition rate. Results: Weiyangning Pill could reduce the frequency of vomiting in pigeons (P <0.05 or P <0.01), inhibit the contractions of rats in vivo (P <0.01), and also inhibit the intestinal contractions induced by acetylcholine Rabbit intestinal spasm significantly inhibited. Conclusion: Weiyangning pill has gastrointestinal spasm, the role of vomiting and its inhibition of gastrointestinal motility.