尽管氟在口腔局部有着很明显的益处 ,但是其副作用氟牙症也通过全身途径发生。在工业化国家 ,包括美国、加拿大 ,龋齿发生率在过去的 40年里明显的降低了。然而 ,美国那些饮用氟化水和非氟化水的社区近 3 0年来氟牙症的流行却在增加。氟牙症与在牙齿发育期氟的摄入密切相关。Fo Although fluoride has obvious local benefits in the oral cavity, its side effects of dental fluorosis also occur through systemic pathways. In industrialized countries, including the United States and Canada, the prevalence of dental caries has dropped dramatically in the past 40 years. However, the prevalence of dental fluorosis in the United States has risen in the last 30 years in those communities that drink fluorinated and non-fluorinated water. Fluorosis is closely related to fluoride intake during tooth development. Fo