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ｔｈｙＡ基因编码胸苷酸合成酶（Ｔｈｙｍｉｄｙｌａｔｅｓｙｎｔｈａｓｅ），在体内ＤＮＡ合成中起关键作用。它催化ｄＵＭＰ向ｄＴＭＰ的转化。ｄＴＭＰ为ＤＮＡ合成的基本原料ｄＴＴＰ的前体〔１〕，同时使５，１０—甲基四氢叶酸转变为７，８—二氢叶酸。胸苷酸合成酶缺陷
The thyA gene encodes thymidylate synthase, which plays a key role in DNA synthesis in vivo. It catalyzes the conversion of dUMP to dTMP. dTMP is the precursor of DNA synthesis dTTP [1], while 5,10-methyltetrahydrofolic acid into 7,8-dihydrofolic acid. Thymidylate synthase deficiency