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淀粉样变性系指淀粉样蛋白在细胞外沉积。淀粉样蛋白是具有一定理化特性、不溶解的蛋白纤维束,有特征性的电镜所见,经刚果红染色后用偏极显微镜检查,纤维呈现苹果绿双折射。它是由正常血清蛋白的多肽分段组成。淀粉样变性分为全身型与局限型两类。已确认的有三种全身型和多种局限型。每一种都有独特的血清蛋白前体;在原发性或伴发骨髓瘤的淀粉样变性(AL)有免疫球蛋白的轻链。在继发性或获得性淀粉样变性有急性期反应物的血清
Amyloidosis refers to the extracellular deposition of amyloid. Amyloid protein is a kind of protein fiber bundle which has certain physicochemical properties and is insoluble. It is seen by the characteristic electron microscope. After being stained with Congo red, it is examined by polarized microscope. The fiber shows apple green birefringence. It is composed of normal serum protein polypeptide fragments. Amyloidosis is divided into two types of systemic and localized. Confirmed there are three types of body and a variety of limitations. Each has a unique serum protein precursor; an amyloid (AL) immunoglobulin light chain in primary or associated myeloma. Serum from secondary or acquired amyloidogenic acute phase reactions