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目的探讨红细胞膜脂质成分的变化与妊高征的关系。方法采用比色法、气相色谱法及全自动生化分析仪对２２例正常妊娠妇女，２４例健康未妊娠妇女，３６例妊高征患者进行红细胞膜磷脂、脂肪酸及胆固醇含量测定。结果（１）中、重度妊高征患者红细胞膜胆固醇含量及胆固醇／磷脂的比值均显著高于正常妊娠及健康未妊娠妇女（Ｐ＜０．０１）；（２）轻度妊高征患者红细胞膜胆固醇含量及胆固醇／磷脂比值与正常妊娠及健康未妊娠妇女比较，差异无显著性（Ｐ＞０．０５）。结论（１）红细胞膜胆固醇含量及胆固醇／磷脂比值的升高，可能是造成红细胞变形能力降低，微循环灌注障碍的主要原因之一，并参与了妊高征的病理生理过程；（２）妊高征患者红细胞膜脂质成分的变化与磷脂及脂肪酸含量无明显相关性，这种膜胆固醇含量的升高可能为血清脂肪代谢紊乱的一种表现
Objective To investigate the relationship between changes of lipid composition in erythrocyte membrane and pregnancy-induced hypertension. Methods The contents of phospholipid, fatty acid and cholesterol in erythrocyte membranes of 22 normal pregnant women, 24 healthy pregnant women and 36 PIH patients were determined by colorimetry, gas chromatography and automatic biochemical analyzer. Results (1), the ratio of erythrocyte membrane cholesterol and cholesterol / phospholipid were significantly higher in patients with severe PIH than those in normal and healthy non-pregnant women (P <0.01); (2) Membrane cholesterol and cholesterol / phospholipid ratio compared with normal and healthy non-pregnant women, no significant difference (P> 0.05). Conclusions (1) Elevated erythrocyte membrane cholesterol and cholesterol / phospholipid ratio may be one of the main reasons for the decrease of erythrocyte deformability and microcirculation perfusion and participate in the pathophysiological process of PIH. (2) There was no significant correlation between lipid composition changes of erythrocyte membrane and phospholipid and fatty acid content in patients with hypercholesterolemia. The increase of cholesterol content in this membrane may be a manifestation of the disorder of serum lipids metabolism