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本文在分子水平上考察药物与模型及生物膜在正常和病理条件下的复杂的理化反应,对已发表的和许多未发表的结构研究结果进行了讨论,并与动力学结合研究相联系,以评估非特异性药物与膜双分子层的相互作用对心脏、大脑中的膜结合受体的结合机制的影响。
This article examines the complex physical and chemical reactions of drugs and models and biofilms under normal and pathological conditions at molecular level and discusses the published and many unpublished structural studies that are linked to kinetic binding studies to The effect of the interaction of the nonspecific drug with the membrane bilayer on the binding mechanism of membrane-bound receptors in the heart and brain was evaluated.