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目的对四川省发生的Ⅱ型疫苗高变异脊髓灰质炎(脊灰)病毒/疫苗衍生脊灰病毒(Circulating TypeⅡVaccine Hyperviariable Poliovirus,cVHPVII/TypeⅡVaccine-derived Poliovirus,cVDPVII)的循环事件,进行流行病学调查和分析,为预防控制脊灰和维持无脊灰提供参考。方法对现场流行病学调查和处置等资料进行描述性分析。结果2011年8月～2012年2月,四川省发生了cVHPVII/cVDPVII事件,现场调查、临床诊断、实验室检测结果表明,此次循环事件共发现4例病例,在4例病例和1名密切接触者粪便标本中分离到VHPVⅡ/VDPVⅡ。结论低口服脊灰减毒活疫苗(Oral Poliomye litis Attenuated Live Vaccine,OPV)接种率是此次事件发生的最主要原因。各级卫生部门所采取的包括急性弛缓性麻痹病例主动搜索、OPV应急免疫等多项措施,阻断了cVHPVII/cVDPVII,控制了事件的扩大和蔓延。
Objective To investigate the epidemiology of circulating type Ⅱ Vaccine Hyperviariable Poliovirus (cVHPVII / Type Ⅱ Vaccine-derived Poliovirus, cVDPVII) Analysis, for the prevention and control of polio and polio to provide reference. Methods Descriptive analysis was conducted on the epidemiological survey and disposal data in the field. Results From August 2011 to February 2012, cVHPVII / cVDPVII occurred in Sichuan Province. The field investigation, clinical diagnosis and laboratory tests showed that 4 cases were found in this cycle, of which 4 cases and 1 were close The contacts were stool specimens isolated VHPV Ⅱ / VDPV Ⅱ. Conclusions The inoculation rate of Oral Poliomye litis Attenuated Live Vaccine (OPV) is the most important cause of this incident. Various measures taken by the health departments at all levels, including the active search of acute flaccid paralysis cases and the emergency immunization of OPV, blocked cVHPVII / cVDPVII and controlled the expansion and spread of the incident.