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目的探讨成人斯蒂尔病合并肝脏损害的发生率、及其发生的相关因素、治疗及预后。方法对52例成人斯蒂尔病患者中出现肝脏损害的37例,分析肝脏损害原因,同时根据病情轻重用保肝降酶、激素等治疗。结果经治疗15 d~6个月,35例肝功能恢复正常,1例肝功能正常后加用来氟米特再次出现严重的药物性肝脏损害,停药治疗后好转,1例治疗原发病过程中自服两倍正常量奥沙普秦片3d后出现急性肝功能衰竭、D IC、最终死亡。结论成人斯蒂尔病合并肝脏损害较常见,应重视合并肝脏损害的患者原发病治疗药物选择,避免在原发病肝脏损害基础上再加药物性肝脏损害。
Objective To investigate the incidence of adult Steyr’s disease complicated with liver damage, its related factors, treatment and prognosis. Methods Totally 37 cases of liver damage were observed in 52 cases of adult patients with Steller disease. The causes of liver damage were analyzed. At the same time, they were treated with H pylori, hormone and other drugs according to their severity. Results After the treatment of 15 d ~ 6 months, 35 cases of liver function returned to normal, 1 case of normal liver function plus leflunomide again serious drug-induced liver damage, withdrawal after treatment improved, 1 case of primary disease During the course of self-service, two times normal oxaliputin appears acute liver failure after 3d, D IC, the final death. Conclusion Adult patients with STD combined with liver damage are more common. Patients with combined liver damage should pay attention to the selection of the treatment of primary disease, and avoid the drug-induced liver damage on the basis of the primary liver damage.