系统性硬皮病(SSc)是一种原因不明的慢性多系统受累的疾病,主要累及女性。不同的临床亚型存在不同的疾病高度特异的自身抗体。外界毒物如氯乙烯,污染的菜子油和硅都可引起SSc样病变,其中硅相关者与特发性SSc最相似。作者检测了硅相关的SSc中自身抗体的特异性,并与特发性SSc相比较,以期发现一有用的自身免疫模型。 Systemic scleroderma (SSc) is a chronic, multisystemic disorder of unknown cause, primarily involving women. Different clinical subtypes have different diseases with highly specific autoantibodies. External poisons such as vinyl chloride, contaminated rapeseed oil, and silicon can all cause SSc-like lesions, with silicon-related persons being most similar to idiopathic SSc. The authors examined the specificity of autoantibodies in silicon-associated SSc and compared it to idiopathic SSc in an attempt to find a useful autoimmune model.