论文部分内容阅读
目的：观察环磷酰胺冲击治疗小儿难治性肾病疗效。方法：环磷酰胺冲击治疗小儿难治性肾病２８例，每２周１次，每次８～１２ｍｇ／ｋｇ，连用２ｄ。其中频反复及频复发６例，激素耐药２２例，经肾活检８例，其中系膜增殖型肾类４例，膜增殖性肾小球肾炎１例，局灶节段性肾小球硬化１例，膜性肾病１例，增生硬化性肾炎１例。结果：总有效率９６％，完全缓解２４例，部分缓解３例。无效１例，６例频反复频复发病例中，４例获长期缓解，１例复发，１例失访。结论：环磷酰胺冲击治疗小儿难治性肾病疗效显著，缓解率高，副作用相对少。是目前治疗小儿难治性肾病强有力的手段和重大进展。
Objective: To observe the effect of cyclophosphamide in the treatment of refractory nephropathy in children. Methods: Cyclophosphamide shock therapy in children with refractory nephropathy in 28 cases, once every 2 weeks, each 8 ~ 12mg / kg, once every 2d. The frequency of repeated and frequency recurrence in 6 cases, hormone resistance in 22 cases, 8 cases by renal biopsy, mesangial proliferative kidney in 4 cases, 1 case of proliferative glomerulonephritis, focal segmental glomerulosclerosis 1 case, 1 case of membranous nephropathy, 1 case of proliferative glomerulonephritis. Results: The total effective rate was 96%, complete remission in 24 cases, partial remission in 3 cases. 1 case was ineffective, and among the 6 cases of frequent recurrent frequency recurrence, 4 cases achieved long-term remission, 1 case recurred, and 1 case lost follow-up. Conclusion: Cyclophosphamide shock treatment of children with refractory renal disease significant effect, high remission rate, relatively few side effects. Is currently a powerful means of treatment of refractory kidney disease in children and significant progress.