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细胞因子可调节神经、内分泌和免疫之间的特定功能联系,白细胞介素-10(IL-10)是新近确定的该类细胞因子之一。IL-10不仅可由淋巴细胞合成,也可在垂体、下丘脑和神经组织产生。IL-10提高下丘脑和垂体中促肾上腺皮质激素释放因子和促肾上腺皮质激素的合成。在下丘脑-垂体-肾上腺轴的下游,IL-10调节糖皮质激素紧张性或应激后的合成。因此,IL-10除了其广泛的免疫调节功能外,它的神经内分泌调节作用表明IL-10是免疫和神经内分泌系统相互联系的重要中介体。本文综述,IL-10在下丘脑-垂体-肾上腺轴的产生和调节功能,并简述其受体机制和信号转导途径。
Cytokines regulate specific functional linkages between nerves, endocrits and immunity, and interleukin-10 (IL-10) is one of these newly identified cytokines. IL-10 can not only be synthesized by lymphocytes, but also in pituitary, hypothalamus and nerve tissue. IL-10 increases corticotropin-releasing factor and adrenocorticotropic hormone synthesis in the hypothalamus and pituitary gland. Downstream of the hypothalamic-pituitary-adrenal axis, IL-10 regulates glucocorticoid stress or post-stress synthesis. Thus, in addition to its extensive immunomodulatory function, IL-10 exerts its neuroendocrine regulatory role indicating that IL-10 is an important mediator of the immune and neuroendocrine system interactions. This article reviews the production and regulation of IL-10 in the hypothalamus-pituitary-adrenal axis and its receptor mechanisms and signal transduction pathways.