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自 Combes 等报告以来,迄今至少报道了6例膜性肾小球肾炎与乙型肝炎病毒感染有关。应用免疫荧光法,可在肾小球毛细血管壁上测到 HBsAg。本文报告的2例均为男孩,有浮肿、蛋白尿,临床及化验检查为肾病综合征表现。肾活检标本在光学显微镜及电子显傲镜下均显示膜性肾小球肾炎之损害。应用反向血凝试验测定患者血清中 HBsAg 及HBeAg,用免疫粘附血凝试验测定抗-HBc,滴度均很高。应用免疫荧光法检查肾活检标本,发现沿着肾小球毛细血管壁上有 IgG 及β_1C 弥散性颗粒状沉淀,切片染色发现有 HBeAg 颗状沉淀,其分布与 IgG 及
To date, at least 6 cases of membranous glomerulonephritis have been reported to have been associated with hepatitis B virus infection since the report by Combes et al. Immunofluorescence was used to detect HBsAg on the glomerular capillaries. Two cases reported in this paper are boys, with edema, proteinuria, clinical and laboratory tests for the performance of nephrotic syndrome. Renal biopsy specimens showed microscopic glomerulonephritis lesions under both light and electron microscopy. HBsAg and HBeAg were measured by reverse hemagglutination test in patients with anti-HBc by immunoadhesion hemagglutination test, the titer is very high. Application of immunofluorescence examination of renal biopsy specimens found along the glomerular capillary wall with IgG and β1C disseminated granular sediment, slice staining found HBeAg pellet, its distribution and IgG and