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随着后基因组时代的到来,蛋白质组学研究的重要性日益显现出来。对于蛋白质结构、功能关系的研究由于局限于技术和手段的发展而进展缓慢。本文对将氢氘交换质谱联用的方法应用于研究蛋白质结构和功能之间关系的进展进行了综述,以期对初涉该领域的研究者以提示。
With the advent of the post-genomic era, the importance of proteomics research is increasingly apparent. For protein structure, the study of functional relationship has been slow due to the limitations of the development of technologies and means. This review summarizes the progress made in the application of hydrogen-deuterium exchange mass spectrometry in the study of the relationship between protein structure and function in the hope of informing researchers involved in this field.