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目的 :探讨血浆内皮素 (ET)及内皮衍生舒张因子 (EDRF)与先天性心脏病 (先心病 )肺动脉高压的关系。方法 :取 30例分流型先心病患者 (先心病组 ) ,其中肺动脉高压者 16例 ,肺动脉压力正常者 14例 ,用右心导管法测其肺循环血流动力学参数。并在心腔内不同部位取血 ,用以检测其ET及EDRF的浓度。并与 30例健康者对照 (对照组 )。结果 :先心病肺动脉高压者肺循环ET产生增加 ,且与肺动脉压力呈正相关 ;而其EDRT产生减少 ,且与肺动脉压力呈负相关 ;肺动脉压力正常者与对照者无差异。结论 :肺动脉高压时ET产生增加 ,而E DRF产生减少 ,可能参与了肺动脉高压形成的病理生理过程
Objective: To investigate the relationship between plasma endothelin (ET) and endothelium-derived relaxing factor (EDRF) and pulmonary hypertension in patients with congenital heart disease (CHD). Methods: Totally 30 patients with CHD (congenital heart disease) were enrolled in this study. Among them, 16 were pulmonary hypertension and 14 were normal pulmonary artery pressure. Their hemodynamic parameters were measured by right heart catheterization. Blood was taken from different parts of the heart cavity to detect the concentrations of ET and EDRF. And 30 healthy controls (control group). Results: Pulmonary cirrhosis with congenital heart disease increased ET production, and pulmonary artery pressure was positively correlated; while its EDRT production decreased, and pulmonary artery pressure was negatively correlated; pulmonary artery pressure was normal and no difference. CONCLUSION: The increase of ET in pulmonary hypertension and the decrease of E DRF may be involved in the pathophysiological process of pulmonary hypertension