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目的 :探讨鳞癌抗原 (SCCAg)在子宫颈鳞癌中的临床应用价值。方法 :微粒子酶免法检测 12 4例子宫颈鳞癌患者治疗前血清SCCAg值 ,对照组 180例为妇科良性疾病患者。早期患者 (Ⅰ～Ⅱa期 )术后一周重复检测SCCAg值 ,部分根治手术患者随诊中监测。结果 :SCCAg在子宫颈鳞癌中的敏感性为 73.4% ,特异性为 96 .1%。SCCAg阳性率随临床分期进展而增高 ,差异有显著性 (P <0 .0 0 5 ) ,早期患者 (Ⅰ期和Ⅱa期 )术前SCCAg值异常者术后均下降至正常水平 ,差异均有显著性 (P <0 .0 0 1)。部分术后患者在 3年随访期内血清SCCAg值在正常水平。结论 :SCCAg是子宫颈鳞癌较特异的肿瘤标志物 ,可以作为子宫颈癌辅助诊断指标 ,评估子宫颈癌手术疗效 ,在早期浸润癌中的临床意义值得进一步研究
Objective: To investigate the clinical value of squamous cell carcinoma antigen (SCCAg) in cervical squamous cell carcinoma. Methods: Serum SCCAg values of 12 4 cases of cervical squamous cell carcinoma before treatment were detected by microparticle enzyme immunoassay, and 180 cases of control group were patients with benign gynecological diseases. Early patients (Ⅰ ~ Ⅱ a) one week after surgery repeated detection of SCCAg values, some patients underwent radical surgery monitoring. Results: The sensitivity of SCCAg in cervical squamous cell carcinoma was 73.4% and the specificity was 96.1%. The positive rate of SCCAg increased with the clinical stage, the difference was significant (P <0.05). In early stage (stageⅠand stageⅡa), the preoperative SCCAg abnormalities decreased to normal levels after operation Significance (P <0. 001). Some postoperative patients in the 3-year follow-up period of serum SCCAg values at normal levels. Conclusion: SCCAg is a specific tumor marker of cervical squamous cell carcinoma, which can be used as an auxiliary diagnostic indicator of cervical cancer to evaluate the curative effect of cervical cancer. The clinical significance of SCCAg deserves further study