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目的:观察卡托普利联合厄贝沙坦治疗高血压及改善左室心肌肥厚疗效。方法:选择高血压患者并行心脏彩超(提示左室心肌肥厚)患者118例,给予卡托普利联合厄贝沙坦口服治疗半年,检查血压及心脏彩超,了解左室舒张末期内径(LVDd)、舒张末期室间隔厚度(IVSd)、左室后壁厚度(LVPWd)、及计算左室重量指数(LVMI)评价疗效。结果:高血压患者治疗后收缩压及舒张压明显降低,左室舒张末期内径、舒张末期室间隔厚度、左室后壁厚度、及计算左室重量指数明显改善。治疗前后对比存在统计学意义(P<0.05)。结论:卡托普利联合厄贝沙坦治疗高血压有效并明显改善左室心肌肥厚。
Objective: To observe the efficacy of captopril combined with irbesartan in the treatment of hypertension and left ventricular hypertrophy. Methods: 118 hypertensive patients undergoing cardiac echocardiography (LVMI) were enrolled. Patients were given captopril and irbesartan orally for six months. The blood pressure and echocardiography were examined. The left ventricular end-diastolic diameter (LVDd) IVSd, LVPWd and LVMI were evaluated. Results: After treatment, systolic blood pressure and diastolic blood pressure were significantly decreased in patients with hypertension. The left ventricular end-diastolic diameter, end-diastolic interventricular septum thickness, left ventricular posterior wall thickness and left ventricular mass index were significantly improved. Before and after treatment there was statistical significance (P <0.05). Conclusion: Captopril combined with irbesartan is effective in treating hypertension and significantly improving left ventricular hypertrophy.