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通过特异性强的过氧化物酶——抗过氧化物酶(PAP)法,我们对一系列临床宫颈疾患中人乳头癌病毒(Human Papillomavirus,HPV)抗原进行了检测,并分析了空泡细胞与抗原检出率的关系,结果表明,在31.3％(5/16)的宫颈不典型增生中和2.1％(1/48)的浸润性宫颈癌中测到了 HPV 抗原,而19例慢性宫颈炎标本中无一例阳性;16例宫颈不典型增生中有11例存在空泡细胞,而这11例空泡细胞阳性的标本中仅有4例 HPV 抗原阳性;16.6％(8/48)的浸润性宫颈癌中存在空泡细胞,但仅有1例标本 HPV 抗原阳性。实验结果提示,HPV 可能与宫颈癌的发生有关,空泡细胞作为诊断宫颈 HPV 感染的特征性标志,值得怀疑。
We examined human papillomavirus (HPV) antigens in a series of clinical cervical disorders by using the specific peroxidase-antiperoxidase (PAP) method and analyzed the effects of vacuolar cells The results showed that HPV antigen was detected in 31.3% (5/16) cervical atypical hyperplasia and 2.1% (1/48) invasive cervical carcinoma, whereas 19 cases of chronic cervicitis None of the 16 cases had vacuolar cells in 11 cases of cervical dysplasia, whereas only 4 cases of HPV positive in these 11 cases of vacuolar cells were positive; 16.6% (8/48) of infiltrative There are vacuolar cells in cervical cancer, but only one specimen was HPV positive. Experimental results suggest that HPV may be related to the occurrence of cervical cancer. Vacuolar cells as a hallmark of diagnosis of cervical HPV infection are questionable.