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目的 研究原发性高血压患者血管紧张素Ⅱ 1型受体 (AT1R)基因A116 6C多态性分布及不同基因型的高血压患者对AT1R拮抗剂伊贝沙坦的治疗反应。方法 采用聚合酶链反应法检测所有研究对象的AT1R基因A116 6C多态性 ,分析C等位基因分布频率。选取轻、中度原发性高血压患者 96例 ,按照基因型分AA型和AC型 ,均给予AT1R拮抗剂伊贝沙坦口服 ,共 85例完成 4周随访 ,比较治疗前后血压、生化指标及不同基因型患者对药物的敏感性。结果 原发性高血压组A116 6C等位基因频率及AC +CC基因型显著高于正常对照组 (P <0 .0 5 ) ;AA基因型和AC基因型的原发性高血压患者服用伊贝沙坦治疗后血压均较治疗前明显下降 (P <0 .0 5 )。不同基因型的患者对伊贝沙坦的敏感性比较无统计学意义。结论 AT1R基因多态性与原发性高血压有关 ;AT1R拮抗剂对所有AT1R基因型的原发性高血压均有良好降压作用 ,没有选择性。
Objective To investigate the distribution of A116 6C polymorphism of angiotensin Ⅱ type 1 receptor (AT1R) gene in patients with essential hypertension and the therapeutic response to AT1R antagonist irbesartan in hypertensive patients with different genotypes. Methods The A116 6C polymorphism of AT1R gene was detected by polymerase chain reaction (PCR) in all subjects and the distribution frequency of C allele was analyzed. A total of 96 patients with mild to moderate essential hypertension were enrolled in this study. According to the genotypes of AA and AC, all of them were given oral inhalation of irbesartan, an AT1R antagonist. A total of 85 patients were followed up for 4 weeks. Blood pressure and biochemical parameters And different genotypes in patients with drug sensitivity. Results The allele frequencies of A116 6C and AC + CC genotypes in patients with essential hypertension were significantly higher than those in controls (P <0.05). Patients with AA and AC genotypes of essential hypertension After treatment, the blood pressure of Beisartan was significantly lower than that before treatment (P <0.05). The sensitivity of different genotypes to irbesartan was not statistically significant. Conclusions AT1R gene polymorphism is associated with essential hypertension. AT1R antagonist has a good antihypertensive effect on all essential hypertension patients with AT1R genotype, with no selectivity.