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目的探讨浙江省富阳地区女性高危型人乳头瘤病毒(HPV)感染率和基因型分布情况。方法采用荧光PCR法,对2013年4月至2015年11月富阳区第一人民医院和富阳区妇幼保健院妇科就诊的13 447例患者宫颈标本检测世界卫生组织(WHO)确认的13种高危HPV型别,包括HPVl6、18、31、33、35、39、45、51、52、56、58、59和68型。结果高危型HPV基因检测感染率为24.57%(3304/13 447),其中单一基因型感染率为17.97%(2416/13 447),多重亚型混合感染率为6.60%(888/13 447);其中以HPV52、HPV16、HPV58三种亚型最多见,所占比例分别为6.51%、5.87%、4.47%。结论浙江省富阳地区妇科就诊女性患者HPV感染以HPV52、HPV16、HPV58三型较多见,常见感染亚型总体符合亚洲国家分布情况,同时又具有其独特的地区分布特点。
Objective To investigate the prevalence and genotype distribution of high risk human papillomavirus (HPV) in Fuyang, Zhejiang Province. Methods Fluorescent PCR was used to detect 13 447 cervical specimens of gynecological patients in Fuyang District First People’s Hospital and Fuyang District Maternal and Child Health Hospital from April 2013 to November 2015. Thirteen high-risk HPVs were identified by World Health Organization (WHO) Types, including HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68. Results The infection rate of high - risk HPV gene was 24.57% (3304/13 447), of which the single genotype infection rate was 17.97% (2416/13 447), and the multiple subtype infection rate was 6.60% (888/13 447). Which HPV52, HPV16, HPV58 three subtypes most common, accounting for 6.51%, 5.87%, 4.47%. Conclusion HPV infection in women with gynecological treatment in Fuyang district of Zhejiang Province is more common with HPV type HPV52, HPV16 and HPV58 types. The common subtypes of infection are generally in line with the distribution of Asian countries and their unique geographical distribution.