Atherton等曾报道亚磷酸二烷基氢酯,四氯化碳或五氯乙烷、六氯乙烷等多卤代烷在碱催化下可使一元伯及仲胺磷酰化合成相应的磷酰胺.此反应亦可使脂肪二元胺磷酰化合成相应的双磷酰胺.但Atherton反应能否使共轭芳香二元胺磷酰化以合成相应的芳香二胺 Atherton et al. Reported that dialkyl hydrogen phosphites, carbon tetrachloride or pentachloroethane, hexachloroethane and other polyhaloalkanes can catalyze the primary and secondary amine phosphorylation to form the corresponding phosphoramides under alkaline catalysis. The reaction can also phosphorylate fatty diamines to the corresponding bisphosphonamides, but whether the Atherton reaction phosphorylates the conjugated aromatic diamines to synthesize the corresponding aromatic diamine