1974年Bottazzo等和MacCuish等首次用间接荧光免疫法在包括Ⅰ型糖尿病(IDDM)的多发性自身免疫性内分泌疾病病人的血液中发现了胰岛细胞抗体,此后,证明在单纯的 IDDM 病人血中亦存在,起病时 ICAs 阳性率较高,随着病程的延长,阳性率下降。ICAs 是非常重要的胰 In 1974, Bottazzo et al. And MacCuish et al. First detected islet cell antibodies in the blood of patients with multiple autoimmune endocrine diseases including type 1 diabetes (IDDM) by indirect immunofluorescence. It was subsequently demonstrated that in pure IDDM patients, Presence, the onset of ICAs positive rate is higher, with the duration of the disease, the positive rate decreased. ICAs are very important to the pancreas