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目的:了解乙型肝炎中高流行地区乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)阴性,乙型肝炎表面抗体/乙型肝炎e抗体/乙型肝炎核心抗体(hepatitis B surface antibody/hepatitis B e antibody/hepatitis B core antibody,anti-HBs/anti-HBe/anti-HBc)阳性肝硬化的病因特点.方法:采用回顾性病例对照研究的方法,以2001-01/2013-12新疆医科大学第一附属医院13年的肝硬化住院病例作为研究对象,根据乙型肝炎五项检测结果将HBsAg阴性,但抗-HBs、抗-HBe、抗-HBc中任意一项阳性的肝硬化作为研究组,将同时期临床确诊为隐源性肝硬化的住院病例作为对照组,比较两组一般情况、合并代谢综合征水平及肝细胞肝癌发生情况等.结果:7012例肝硬化住院病例中,符合HBsAg阴性、抗-HBs/抗-HBe/抗-HBc阳性肝硬化220例(占3.14%),符合隐源性肝硬化147例(占2.10%).两组患者,研究组年龄均数显著性低于对照组(P<0.05)、男性患者构成比显著性高于对照组(P<0.05)、汉族患者比例高(P<0.05),研究组具有更高的肝癌发生率(P<0.05),而合并糖尿病、高血压的发生率显著性低于隐源性肝硬化组(P<0.05).结论:HBsAg阴性、抗-HBs/抗-HBe/抗-HBc阳性肝硬化与隐源性肝硬化患者在性别、年龄、合并代谢综合征水平及肝细胞肝癌发生情况等方面均存在统计学差异,提示乙型肝炎标志物阳性组肝硬化患者的病因与隐源性肝硬化存在不同的致病因素,该项研究有助于指导临床医师对两组肝硬化患者的病因诊断.
Objective: To investigate the prevalence of hepatitis B surface antigen (HBsAg), hepatitis B surface antigen (HBsAg) / hepatitis B surface antibody / hepatitis B e antibody / hepatitis B core antibody, anti-HBs / anti-HBe / anti-HBc) in patients with cirrhosis.Methods: By retrospective case-control study, Affiliated Hospital of 13-year liver cirrhosis hospitalized cases as the research object, according to five tests of hepatitis B will HBsAg negative, but anti-HBs, anti-HBe, anti-HBc in any one of the positive cirrhosis as a research group will be At the same time, the clinical diagnosis of cryptogenic cirrhosis in hospital as control group, the two groups were compared in general, with metabolic syndrome and hepatocellular carcinoma occurrence.Results: 7012 cases of cirrhosis in hospital, in line with HBsAg-negative, Anti-HBs / anti-HBe / anti-HBc positive cirrhosis 220 cases (3.14%), in line with cryptogenic cirrhosis in 147 cases (2.10%) .In two groups of patients, the study group was significantly lower age mean Group (P <0.05), male patient structure (P <0.05), the proportion of Han patients was higher (P <0.05), and the study group had a higher incidence of hepatocellular carcinoma (P <0.05), while the incidence of diabetes mellitus and hypertension was significantly higher than that of the control group (P <0.05) .Conclusion: HBsAg-negative, anti-HBs / anti-HBe / anti-HBc positive cirrhosis and cryptogenic cirrhosis were significantly different in sex, age, combined metabolic syndrome And hepatocellular carcinoma occurred statistically significant differences, suggesting that hepatitis B-positive patients with cirrhosis of the etiology and cryptogenic cirrhosis of the existence of different risk factors, the study will help guide the clinician Two patients with cirrhosis etiology diagnosis.