目的:分析肺部磨玻璃结节随访中的变化和干预情况，探讨肺部磨玻璃结节的生长规律。方法:纳入2017年10月至2019年6月复旦大学附属中山医院门诊随访的肺部磨玻璃结节2 247例，其中男633例，女1 614例，平均年龄49.9岁。分析其随访过程中接受治疗的情况和结节变化情况。结果:266例选择手术治疗，1 981例继续随访中。继续随访的患者随访(35.5±21.1)个月，中位随访29(12～165)个月；手术患者随访(19.5±18.5)个月，中位随访13(3～97)个月。手术的266例患者中，19例磨玻璃结节进展，166例磨玻璃结节未进展，81例未知是否进展，在外院手术。结节进展和未进展的患者术后病理和手术方式无显著差异，进展组纯磨玻璃结节的基线最大径明显大于未进展组[(1.3±0.5)cm对(0.9±0.4)cm，n P＝0.038]。n 结论:磨玻璃结节进展缓慢，进展后再进行手术并不影响手术的方式和效果。“,”Objective:To analyze the changes and interventions of pulmonary ground glass nodules during follow-up, and to investigate the growth rules of pulmonary ground glass nodules.Methods:A total of 2 247 cases of pulmonary ground glass nodules were included from October 2017 to June 2019. There were 633 males and 1 614 females, with an average age of 49.9 years old. The treatment and changes of nodules were analyzed.Results:Two hundred and sixty-six patients received surgery, and the remaining 1 981 patients were still in follow-up. The average follow-up time for patients who continued to follow-up was (35.5±21.1) months, the median follow-up time was 29(12-165) months, the average follow-up time for surgical patients was (19.5±18.5) months, and the median follow-up time was 13(3-97)months. Of the 266 patients who underwent surgery, 19 were due to the progression of ground glass nodules, 166 ground glass nodules did not change, and 81 patients received surgery in other hospitals without knowing whether the changes occurred. There was no significant difference in postoperative pathology and surgical methods between patients with and without nodular progression. The baseline mean maximum diameter of pure ground glass nodules in the progression group was significantly greater than that in the non-progression group[(1.3±0.5)cm vs. (0.9±0.4)cm, n P=0.038].n Conclusion:Ground glass nodules progress slowly, and surgery after progress does not affect the method and effect of the surgery.