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目的探讨检测尿液中HA含量诊断膀胱癌的价值。方法搜集膀胱癌患者47例及健康查体对象21例的尿液标本，采用ELISA样方法测定其中HA含量。结果47例膀胱癌患者尿液中HA平均含量为332.43±46.8ng／mg，21例正常对照组者为116.4±17.2ng／mg，两者有非常显著性差异（P＜0.001）。G3组HA平均含量较G1组者明显为高（P＜0.01）；与Ta期相比，T1、T2期患者尿液中HA水平均明显升高（P＜0.01）。以大于正常对照组尿液中HA水平上限即133.6ng／mg为阳性界值时，检测尿液中HA水平诊断膀胱癌的敏感度为89.9%（42／47），特异度为90.5%（19/21）。结论尿液中HA含量检测方法简便，无创伤性，且具有较高的敏感度从特异度，可作为膀胱癌的辅助诊断措施。
Objective To investigate the value of detecting the content of HA in urine to diagnose bladder cancer. Methods Urine samples from 47 patients with bladder cancer and 21 healthy controls were collected and the content of HA was measured by ELISA. Results The average content of HA in urine of 47 patients with bladder cancer was 332.43 ± 46.8 ng / mg and that of 21 normal controls was 116.4 ± 17.2 ng / mg. There was a significant difference between the two (P <0.001). The level of HA in G3 group was significantly higher than that in G1 group (P <0.01). Compared with Ta group, the level of HA in T1 and T2 stage patients was significantly increased (P <0.01). When the HA level in the urine was higher than the upper limit of HA in the normal control group, which was 133.6ng / mg, the sensitivity and specificity of detection of HA in urine were 89.9% (42/47) and 90.5% (19%) respectively /twenty one). Conclusion The detection method of HA in urine is simple, non-invasive, and has high sensitivity and specificity, which can be used as auxiliary diagnosis of bladder cancer.