论文部分内容阅读
B-type natriuretic peptide(BNP) and the N-terminus of pro-BNP(NT-pro-BNP) have prognostic value in patients with heart failure and patients with acute coronary syndromes. Little is known about the prognostic value of baseline NT-pro-BNP alone or in combination with C-reactive protein(CRP) for clinical outcome after percutaneous coronary intervention(PCI). Within a single center registry of contemporaneous PCI, we investigated the prognostic value of baseline plasma NT-pro-BNP and CRP concentrations for the prediction of death or nonfatal myocardial infarction(MI) during 12 to 14 months of follow-up. Among 1,172 consecutive patients, the occurrence of death or MI increased significantly with baseline NT-pro-BNP before PCI(first quartile 0 of 294, second quartile 6 of 291[2.1%], third quartile 4 of 294[1.4%], fourth quartile 22 of 293[7.5%)]; p< 0.0001). NT-pro-BNP in the top quartile significantly predicted death(odds ratio[OR] 13.37, 95%confidence interval[CI] 4.50 to 40.38, p< 0.0001) and was associated with nonfatal MI(OR 2.53, 95%CI 0.77 to 8.34, p=0.22)An abnormal CRP was significantly associated with death(OR 3.47, 95%CI 1.26 to 9.54, p=0.019). Stepwise multivariate logistic regression analysis identified age >65 years and NT-pro-BNP as independent significant predictors of death/MI(age OR 3.18, 95%CI 1.32 to 7.67, p=0.01; NT-pro-BNP OR 4.57, 95%CI 2.07 to 10.10, p=0.0001). Baseline NT-pro-BNP before PCI provides important, independent prognostic information for the occurrence of death or nonfatal MI during long-term follow-up.
B-type natriuretic peptide (BNP) and the N-terminus of pro-BNP (NT-pro-BNP) have prognostic value in patients with heart failure and patients with acute coronary syndromes. Little is known about the prognostic value of baseline NT- Pro-BNP alone or in combination with C-reactive protein (CRP) for clinical outcome after percutaneous coronary intervention (PCI). Within a single center registry of contemporaneous PCI, we investigated the prognostic value of baseline plasma NT-pro-BNP and CRP concentrations for the prediction of death or nonfatal myocardial infarction (MI) during 12 to 14 months of follow-up. Among 1,172 consecutive patients, the occurrence of death or MI increased significantly with baseline NT-pro-BNP before PCI (first quartile 0 of 294, second quartile 6 of 291 [2.1%], third quartile 4 of 294 [1.4%], fourth quartile 22 of 293 [7.5%]]; p <0.0001) (odds ratio [OR] 13.37, 95% confidence interval [CI] 4.50 to 40.38, p <0.0001) and was associated with nonfatal MI (OR 2.53, 95% CI 0.77 to 8.34, p = 0.22) An abnormal CRP was significantly associated with death (OR 3.47, 95% CI 1.26 to 9.54, p = 0.019). Stepwise multivariate logistic regression analysis identified age> 65 years and NT-pro-BNP as independent significant predictors of death / MI (age OR 3.18, 95% CI 1.32 to 7.67, p = 0.01; NT-pro- BNP OR 4.57, 95% CI 2.07 to 10.10, p = 0.0001). Baseline NT-pro-BNP before PCI provides important, independent prognostic information for the occurrence of death or nonfatal MI during long-term follow-up.