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目的分析乙型肝炎病毒(hepatitis B virus,HBV)感染孕妇分娩前HBV-DNA载量与婴儿HBV宫内感染免疫失败的关系,分析不同HBV-DNA载量孕妇的婴儿免疫失败情况。方法选择住院分娩HBV-DNA阳性孕妇及对应婴儿各878例,按照母亲HBV-DNA载量将其对应婴儿分为4组,A组315例,母亲5.0×102copies/mL1.0×108copies/mL者免疫失败率显著增加。
Objective To analyze the relationship between the HBV-DNA load before delivery and the immune failure of intrauterine infection in pregnant women with hepatitis B virus (HBV) infection, and analyze the infant’s immune failure in different HBV-DNA pregnant women. Methods 878 HBV-DNA positive pregnant women and their corresponding infants in hospital were selected. The corresponding infants were divided into 4 groups according to the mother’s HBV-DNA load. Group A received 315 pregnant women, mothers 5.0 × 102copies / mL 106copies / mL in group B; 126 mothers in HBV-DNA (1.0-9.9) x 106copies / mL; 292 in group C, mothers HBV-DNA 1.0-9.9 107copies / mL in group B; 145 in group D; DNA ≧ 1.0 × 108 copies / mL. To analyze the relationship between mothers’ HBV-DNA load and the rate of immune failure after primary and passive immunization of hepatitis B in infants. Results 878 infants were HBV-DNA positive in 36 cases at birth, of which 29 cases failed to immunize. The immune failure rates in groups A, B, C and D were 0, 3.18%, 3.42% and 10.34%, respectively Significance (χ2 = 56.88, P <0.01). Conclusions The intrauterine infection failed in immunization with HBV-DNA≥1.0 × 106copies / mL before delivery and HBV-DNA> 1.0 × 108copies / mL.