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目的探讨不同肝病患者血清腺苷脱氨酶(ADA)的变化及其临床意义。方法用全自动生化分析仪测定了212例不同肝病患者血清ADA活性。结果肝病患者ADA因病情不同而有不同程度的升高。肝硬变、急性肝炎、肝癌、重症肝炎、慢性肝炎ADA分别为(39.9±10.8)、(37.2±14.9)、(35.7±15.1)、(28.6±12.7)、(26.3±8.6)U/L。肝硬化组ADA明显升高,其次是急性肝炎和肝癌组,重症肝炎组和慢性肝炎组ADA轻度升高。结论ADA可以较好反映急性肝炎的残存病变,可协助诊断慢性肝病,是肝病尤其是肝硬化诊断和治疗中监测的良好指标,检测肝脏疾病患者的ADA活性,对于了解肝脏疾病的病理生理变化,鉴别各型肝炎,评价疗效、判断肝病预后,有着重要的临床意义。
Objective To investigate the changes of serum adenosine deaminase (ADA) in patients with different liver diseases and its clinical significance. Methods Serum ADA activity in 212 patients with different liver diseases was measured by automatic biochemical analyzer. Results ADA patients with liver disease due to different conditions have different degrees of elevation. The ADA of cirrhosis, acute hepatitis, liver cancer, severe hepatitis and chronic hepatitis were (39.9 ± 10.8), (37.2 ± 14.9), (35.7 ± 15.1), (28.6 ± 12.7) and (26.3 ± 8.6) U / L respectively. ADA was significantly higher in cirrhotic patients, followed by mild ADA in acute hepatitis and hepatocellular carcinoma, severe hepatitis and chronic hepatitis. Conclusion ADA can better reflect the residual disease of acute hepatitis, can help diagnose chronic liver disease, is a good indicator of liver disease, especially in the diagnosis and treatment of liver cirrhosis. Detecting ADA activity in patients with liver disease, to understand the pathophysiological changes of liver disease, Identification of various types of hepatitis, evaluation of efficacy, to determine the prognosis of liver disease, has important clinical significance.