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前已报道含β环糊精(β-CD)复合物直肠用栓剂的物理化学特性与稳定性。本文研究了茴香油-和吲哚美辛(消炎痛)-β-CD 两种栓剂的溶出和吸收。同时以单纯药物栓剂作为对照品。结果证明,上述复合物栓剂与其口服制剂类似,能提高茴香油和吲哚美辛的溶出分别为5～6倍和2～3倍。此外,还观察到制备β-CD复合物时,结晶方法不同也可影响溶出速率。按下法制备了四种不同茴香油-β-CD 复合物:将β-CD 溶于30%
The physico-chemical properties and stability of suppositories with β-cyclodextrin (β-CD) rectum have been previously reported. In this paper, we studied the dissolution and absorption of both anise oil and indometacin (indomethacin) -β-CD suppositories. At the same time as a simple drug suppository as a reference substance. The results show that the compound suppository similar to its oral formulations can improve the eugenol and indometacin dissolution were 5 to 6 times and 2 to 3 times. In addition, it has also been observed that the different crystallization methods also affect the dissolution rate when preparing the β-CD complex. Four different anise oil-β-CD complexes were prepared by the following method: β-CD was dissolved in 30%