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应用单克隆抗体（ＭｃＡｂ）和免疫荧光技术检测了６３例慢性肾功能衰竭（ＣＲＦ）患者和２７例健康人的Ｔ淋巴细胞总数（ＯＫＴ３）、辅助性Ｔ细胞（ＯＫＴ４）、抑制性Ｔ细胞（ＯＫＴ８）及ＯＫＴ４／ＯＫＴ８比值；同时给予锌剂观察补锌对ＣＲＦ患者Ｔ淋巴细胞亚群的作用，结果：补锌后ＣＲＦ患者的ＯＫＴ３、ＯＫＴ４较补锌前显著上升（Ｐ＜０．０１），ＯＫＴ８较补锌前下降，但没有明显差异（Ｐ＞０．０５），ＯＫＴ４／ＯＫＴ８较正常人上升（Ｐ＜０．０１），提示补锌对慢性肾衰患者Ｔ淋巴亚细胞群有调节作用。
The total number of T lymphocytes (OKT3), OKT4, suppressor T cells (T lymphocytes) in 63 patients with chronic renal failure (CRF) and 27 healthy controls were detected by monoclonal antibody and immunofluorescence techniques OKT8), and OKT4 / OKT8 ratio. At the same time, the effect of zinc supplementation on T lymphocyte subsets in CRF patients was observed. Results: OKT3 and OKT4 increased significantly (P <0.01) , OKT8 decreased compared with that before zinc supplementation, but there was no significant difference (P> 0.05), OKT4 / OKT8 increased compared with normal people (P <0.01), suggesting that zinc supplementation could regulate T lymphocyte subsets in patients with chronic renal failure effect.