论文部分内容阅读
对恶性肿瘤７０例（恶性组）、良性肿瘤５０例（良性组）和正常健康妇女５０例（对照组）尿中半抗氨酸蛋白酶（ＵＣＰ）活性进行测定。结果：ＵＣＰ辅助诊断恶性肿瘤的敏感性为９０％、特异性为８０％、准确性为８６％。恶性组ＵＣＰ值明显高于良性组和对照组（Ｐ＜０．０１）。ＵＣＰ检测对卵巢癌尤为敏感，敏感性为９５％，高于子宫体癌（７７％）、宫颈癌（８５％）。ＵＣＰ、血清肿瘤标记物ＣＡ＿（１２５）及乳酸脱氢酶（ＬＤＨ）同功酶辅助诊断卵巢癌的敏感性依次为９０％、８５％、７５％；特异性为８０％、８７％、８５％；准确性为８４％、８４％、８０％。ＵＣＰ与ＣＡ＿（１２５）对卵巢癌的辅助诊断有同样的价值，而且优于ＬＤＨ同功酶。８例卵巢癌Ⅰ期患者，７例ＵＣＰ值异常，而同组６例卵巢癌Ⅰ期患者中，无１例ＣＡ＿（１２５）值异常，说明ＵＣＰ检测对早期卵巢癌较ＣＡ＿（１２５）更敏感。提示：ＵＣＰ可能成为妇科恶性肿瘤，特别是卵巢癌的标记物。
Urinary semi-active proteinase (UCP) activity was measured in 70 patients with malignant tumor (malignant group), 50 benign tumor (benign group) and 50 normal healthy women (control group). Results: The sensitivity of UCP in the diagnosis of malignant tumors was 90%, the specificity was 80% and the accuracy was 86%. The UCP value of malignant group was significantly higher than that of benign group and control group (P <0.01). UCP detection is particularly sensitive to ovarian cancer with a sensitivity of 95%, higher than that of endometrial cancer (77%) and cervical cancer (85%). The sensitivity of UCP, serum tumor marker CA 125 and lactate dehydrogenase (LDH) isozyme in the diagnosis of ovarian cancer were 90%, 85%, 75%, specificity 80%, 87%, 85% ; Accuracy of 84%, 84%, 80%. UCP and CA 125 have the same value in the diagnosis of ovarian cancer and are superior to LDH isoenzyme. In 8 patients with stage Ⅰ ovarian cancer, 7 patients had abnormal UCP value, but none of 6 patients with stage Ⅰ ovarian cancer in the same group had abnormal CA 125 value, indicating that UCP was more sensitive to early stage ovarian cancer than CA 125. . Tip: UCP may become a gynecological malignancy, especially ovarian cancer markers.