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据报道,口服类固醇避孕药可引起一些类似早期动脉粥样硬化的血脂改变,如高密度脂蛋白胆固醇(HDL-C)水平下降,甘油三酯水平升高等。Steel观察到青年糖尿病妇女使用含有雌激素的避孕药后,心及脑血管疾病发病率增高。为比较不同类型避孕药对糖尿病人糖、脂代谢的影响,作者对25例胰岛素依赖型青年糖尿病妇女随机交叉分组,分别使用只含小剂量孕激素(炔雌烯醇 lynestrenol 0.5mg,简称L 组)或联合孕,雌激素(乙炔雌二醇 ethinyl estra-diol 50μg+lynestrenol 2.5mg,简称 LE 组)。服药持续6个月,在用药前及用药后第1、3、6月测定病人的血糖及血脂。
It has been reported that oral steroid contraceptives can cause some similar early atherosclerosis lipid changes, such as high-density lipoprotein cholesterol (HDL-C) levels, triglyceride levels and so on. Steel observed an increase in the incidence of heart and cerebrovascular disease in young diabetic women using birth control pills containing estrogen. In order to compare the effects of different types of contraceptives on glucose and lipid metabolism in diabetic patients, 25 randomly selected insulin-dependent diabetic women were divided into two groups randomly: low-dose progestin (lynestrenol 0.5mg, L group ) Or combined pregnancy, estrogen (ethinyl estra-diol 50μg + lynestrenol 2.5mg, referred to as LE group). The medication lasted 6 months, before treatment and after the first 1, 3, 6 months to determine the patient’s blood glucose and blood lipids.