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目的设计并合成新型苯并咪唑类衍生物。方法用苯并咪唑代替先导化合物吡唑亚胺类衍生物的吡唑环。结果成功合成了结构新颖的苯并咪唑类衍生物,并采用了~1H NMR、MS进行结构确证。结论合成了3个结构新颖的苯并咪唑类衍生物,为后续测定大麻Ⅱ型受体(CB2)活性提供了基础。
Aim To design and synthesize novel benzimidazole derivatives. Methods The pyrazole ring of pyrazole imine derivative was replaced by benzimidazole. Results The novel benzimidazole derivatives were successfully synthesized and confirmed by 1H NMR and MS. Conclusion Three novel benzimidazole derivatives were synthesized, which provided a basis for the subsequent determination of the activity of the cannabinoid type Ⅱ receptor (CB2).