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6年来我院收治Rh 系统血型不合孕妇6例,孕妇体内IgG 抗D 抗体(+)者3例,抗E 抗体(+)2例,抗C 抗体(+)1例.抗体效价5例为1:64,1例抗C 为1:32.在妊娠20周以后用血液细胞分离机将含IgG 抗体的孕妇血浆分离,红细胞与不含抗体的异体同型冷冻新鲜血浆混合后,再输回母体,以降低抗体效价.每次置抉血浆600～1000ml.6例中3例置换3次,2例置换2次,1例置换1次.于孕36~(+1)～38~(+2)周行计划分娩.仅1例行新生儿换血,术后3天因感染死亡,余5例均行一般疗法痊愈出院.新生儿成活率达83%.此法为对胎儿无损害可减轻新生儿溶血症,避免行新生儿换血的治疗方法.
6 cases of Rh-type unrelated pregnant women admitted to our hospital in 6 cases, 3 cases of IgG anti-D antibody (+) in pregnant women, 2 cases of anti-E antibody (+) and anti-C antibody 1: 64, 1 case of anti-C 1:32 in pregnancy after 20 weeks with a blood cell separator with IgG antibody-containing pregnant women plasma separation, red blood cells and antibody-free allogeneic frozen fresh plasma mixed before being returned to the mother , In order to reduce the antibody titer.Each time to set the plasma 600 ~ 1000ml 6 cases, 3 cases were replaced 3 times, 2 cases were replaced 2 times, 1 case of replacement 1. In pregnant 36 ~ (+1) ~ 38 ~ (+ 2) Weekly scheduled childbirth. Only 1 routine newborn blood transfusion, 3 days after the death due to infection, the remaining 5 cases were cured and discharged. Neonatal survival rate of 83%. This method is no damage to the fetus can be reduced Neonatal hemolytic disease, to avoid neonatal blood transfusion treatment.