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夜间一次服用H_2受体拮抗剂产生明显的抑制夜间胃酸的分泌而不明显减少白天的胃酸度。初步治疗研究已证实这种治疗是有效的。除对病人更方便外,夜间疗法从生理学方面来看也是有吸引力的,因为它较少干扰胃酸的分泌。作者最近对推荐用H_2受体拮抗剂治疗12,000多名十二指肠溃疡病人所发表的100多次临床试验的全部资材做了综述。下表表明夜间仅一次给予中等剂量的H_2受体拮抗剂8周能获得95％以上的治愈率。这些资料有力地支持了夜间一次给药产生最高治愈率的论点。从下表还可明显看出4—8周的连续治疗引起
Overnight use of H 2 receptor antagonists produces significant inhibition of nocturnal gastric acid secretion without significant reduction of daytime gastric acidity. Preliminary treatment studies have demonstrated that this treatment is effective. In addition to being more convenient for the patient, nighttime therapy is also physiologically attractive as it less interferes with gastric acid secretion. The authors recently reviewed all of the more than 100 clinical trials published for more than 12,000 patients with duodenal ulcer recommended for H 2 receptor antagonists. The table below shows that a single dose of a H 2 receptor antagonist at a single dose at night for eight weeks yielded a cure rate of more than 95%. These data strongly support the claim that the highest rate of cure at one time during the night is administered. It is also evident from the table below that 4-8 weeks of continuous treatment is caused