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报道新免疫抑制剂FK-506(FK)抑制异种间脑移植排斥反应的实验研究效果.采用镜下摘除14日龄SD大白鼠黑质细胞在内的腹侧中脑组织,作为固形组织移植于生后8周龄的C_3H/He小白鼠右侧脑室,移植后连日皮下注射FK或生理盐水.将宿主分为3组:A组给予FK10.0mg/kg/d(n=5);B组给予FK1.0mg/Kg/d(n=5);C组(对照组)投予生理盐水0.1ml/day(n=5).3组均于移植14日后用4%多聚甲醇灌流固定,取脑,浸润固定后脱水冰冻,切成16～20μm的薄片,进行苏木精—曙红及Nissl染
Reported the new immunosuppressive agent FK-506 (FK) inhibition of xenotransplantation brain transplantation rejection experimental results using the removal of 14-day-old SD rat substantia nigra cells, including ventral mesencephalic tissue, as a solid tissue transplanted in The right ventricle of 8-week-old C_3H / He mice were injected subcutaneously with FK or normal saline on day after transplantation.The hosts were divided into 3 groups: group A was given FK10.0mg / kg / d (n = 5); group B (N = 5), FK1.0mg / Kg / d (n = 5), C group (control group), physiological saline 0.1ml / day (n = 5) .The three groups were all fixed with 4% Take the brain, fixed after the wet dehydration, cut into 16 ~ 20μm sheet, hematoxylin - eosin and Nissl staining