论文部分内容阅读
卡那霉素的光譜作用与新霉素相近,其化学結构亦相似。它具有神經型毒素的副作用。若每昼夜注射1.5—2克(用卡那霉素治疗結核时的剂量),超过40克后即能引起耳聋,作者观察了用卡那霉素治疗的81个病人,有20人有听觉障碍。卡那霉素与鏈霉素一样能損害耳蝸前庭,尤其在腎脏排泻功能不好的情况下其毒性作用特別快。另外,曾記載用卡那霉素治疗引起視觉障碍者2例。由皮肤的敏感性增高,可以看出对其他神經系統的損害。作者着重指出,在治疗过程中必須重复进行听力的測驗。
The spectral effect of kanamycin and neomycin similar, its chemical structure is also similar. It has the negative effects of neurotoxins. If 1.5-2 g per day and night (doses of kanamycin for tuberculosis) are in excess of 40 g to cause deafness, the authors observed 81 patients treated with kanamycin and 20 with hearing loss . Kanamycin and streptomycin can damage the vestibule of the cochlea, especially in the case of poor renal diarrhea, its toxicity is particularly fast. In addition, it has been described that 2 cases of visual impairment were treated with kanamycin. Sensitivity to the skin increased, you can see the damage to other nervous systems. The authors emphasize that hearing tests must be repeated during treatment.