【摘 要】
：
Direct methods that enable stereoselective functionalization of C(sp~3)–H bonds could facilitate efficient preparation of therapeutics and agrochemicals,and sh
【机 构】
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State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking Univ
【出 处】
：
Science China(Chemistry)
论文部分内容阅读
Direct methods that enable stereoselective functionalization of C(sp~3)–H bonds could facilitate efficient preparation of therapeutics and agrochemicals,and shall have a major effect on the discovery and development of new pharmaceuticals.Although the transformations through C(sp~2)–H bond cleavage have been significantly developed in the past decades,the direct C(sp~3)–H functionalization,especially the asymmetric transformation is still a big challenge.Demon-
Direct methods that enable stereoselective functionalization of C (sp ~ 3) -H bonds may facilitate efficient preparation of therapeutics and agrochemicals, and shall have a major effect on the discovery and development of new pharmaceuticals. Although the transformations through C (sp ~ 2) -H bond cleavage have been significantly developed in past decades, the direct C (sp ~ 3) -H functionalization, especially the asymmetric transformation is still a big challenge. Detect-
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