To explore the role of tissue harmonic imaging(THI) in differentiating hepatocellular carcinoma (HCC), liver metastasis and hemangioma.Methods TOSHIBA SSA-370A ultrasonic system with a 3-to 6-MHz convex transducer (PMV-375AT) was utilized for the study.68 patients(30 cases of HCC, 14 liver metastasis, 24 cases of hemangioma) were examined with fundamental imaging(FI) and tissue harmonic imaging ( THI). Signal-to-noise ratio (SNR), tissue structure parameter:coefficient of variation(CTV) and specific coefficient of variation(CTVs) were calculated, then the tendency of each parameter in every group was evaluated.Results CTV and CTVs within group had no difference, but those between the groups had significant difference(P<0. 05). As a good parameter, CTVs could correctly discriminate HCC, liver metastasis and hemangioma in three groups. It showed that the value of SNR was the highest in hemangioma and the lowest in liver metastasis, and it showed the tendency of increment of the value with a decreased frequ To explore the role of tissue harmonic imaging (THI) in differentiating hepatocellular carcinoma (HCC), liver metastasis and hemangioma. Methods TOSHIBA SSA-370A ultrasonic system with a 3- to 6-MHz convex transducer (PMV- 375AT) was utilized for the study-68 patients (30 cases of HCC, 14 liver metastasis, 24 cases of hemangioma) were examined with fundamental imaging (FI) and tissue harmonic imaging (THI). Signal-to-noise ratio of variation (CTV) and specific coefficient of variation (CTVs) were calculated, then the tendency of each parameter in every group was was as.Results CTV and CTVs within group had no difference, but those between the groups had significant difference (P <0 . 05 showed that the value of the value of SNR was the highest in hemangioma and the lowest in liver metastasis, and it showed the tendency of increment of. the value wit h a decreased frequ